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22 Jun 2020 ... (B) Cocrystal structures of KRASG12C in complex with the various binders show the highly similar binding modes of these compounds. No ...
1 May 2020 ... ... and comparison of KRAS proteoforms by top-down mass spectrometry ... KRAS4A, which not only exhibits differential PTM to KRAS4B, but varies widely in both ... Fellers RT, Whiteley G, Boja ES, Rodriguez H, Kelleher NL.
29 Oct 2019 ... As yet, there are no drugs approved against RAS proteins, of which ... the KRAS signalling is shut down at the drug target and the 'volume' of ...
7 Jan 2013 ... Ras GTPases: Codon Bias Holds KRas Down but Not Out ... B.M. Willumsen, A. Christensen, N.L. Hubbert, A.G. Papageorge, D.R. LowyThe ...
1 May 2012 ... Down-regulation of miRNA-143 was observed in 47 out of 77 (61%) tumours. ... No role for miRNA-143 expression as a predictive biomarker for ... Shyr Y, Slebos RJ, Chung CH (2010) Regulation of heparin-binding EGF-like ...
9 Feb 2012 ... STK33 kinase inhibitor BRD-8899 has no effect on KRAS-dependent cancer cell viability ... Knock down of STK33 was reported to induce apoptosis in ... HTRF Transcreener ADP assay was purchased from Cis-bio US ...
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ing away paraffin blocks with tumor tissue for KRAS mutation testing may not be ... In summary, the pathologists looking down ... e-mail: [email protected].
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14 Jan 2016 ... KRAS mutation, but not ... not convey additional benefit for patients with advanced ... when we narrowed it down to the kinase domain of. HER2.
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